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• W2375047896 abstract "Objective To investigate the effects of animal preparation on microPET imaging of tumor xenografts in nude mice and optimize the imaging protocol. Methods Thirty-six nude mice implanted with human epidermoid carcinoma A431cells were randomly divided into 6 groups. Group A: no fasting,room temperature( 20℃ to 22℃),no anesthesia( leaving the animal awake for 60 min after the18F-FDG injection),and18F-FDG given by i. v. injection. Group B: Fasting( 6 to 8 h),warming( 30℃ to 32℃),anesthesia( inhaling 2% isoflurane anesthesia),and18F-FDG given by i. v. injection. Group C: No fasting,warming,anesthesia,and18F-FDG given by i. v. injection. Group D: Fasting,room temperature,anesthesia,and18F-FDG given by i. v. injection. Group E: Fasting,warming,no anesthesia,and FDG given by i. v. injection. Group F: Fasting,warming,anesthesia,and18F-FDG was given by i. p. injection. Serum glucose level was measured before FDG injection. % ID / g max of the subcutaneous tumor,neck muscle,brown adipose tissue,brain, liver,kidney,myocardium,harderian gland of the groups A to F were measured after scanning. Results( 1) The tumor 18F-FDG uptake was significantly inversely correlated with glycemia in the groups B,C and F( P 0. 05).( 2) The18FFDG uptakes in the brown adipose and muscle tissues in the group A were 8. 03 ± 1. 29 and 16. 07 ± 5. 20,respectively. The18F-FDG uptakes in the brown adipose and muscle tissues in the group B were decreased by 71. 98% and 81. 84%, respectively,than that in the group A( P 0. 05). The uptake in the cervical muscles was highest in the group A( 16. 07 ± 5. 20),and lowest in the group B,being 81. 84% lower than that of the group A( P = 0. 000). The uptakes by brain, liver,kidney,myocardium and harderian gland were not significantly different among different groups.( 3) The tumor-toorgan uptake ratio was lowest in the group A. The tumor-to-muscle,tumor-to-liver and tumor-to-brown fat uptake ratios were 6. 5-fold,1. 29-fold and 4. 76-fold increased,respectively,in the group B than that in the group A( P 0. 05 for all). Under the experimental conditions of group B,the image contrast of tumor and organs was improved.( 4) No significant differences were found for tumor18F-FDG uptake by different routes of injection in the first scanning( P = 0. 364). After the second scanning,the18F-FDG accumulation in the abdominal cavity by intraperitoneal injection led to a lower uptake of tumor and normal tissues. Significant differences were found for tumor18F-FDG uptake by intraperitoneal injection between the first scanning and the second scanning( P = 0. 025). Conclusions Animal preparation has significant effects on the18F-FDG biodistribution in normal tissues and the uptake in subcutaneously transplanted tumors. Fasting,warming,anesthesia,intravenous injection can improve the imaging quality and reproducibility." @default.
• W2375047896 created "2016-06-24" @default.
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• W2375047896 date "2014-01-01" @default.
• W2375047896 modified "2023-09-27" @default.
• W2375047896 title "Effects of animal preparation on the microPET imaging in nude mouse tumor xenografts" @default.
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