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- W2375052328 abstract "Objective To discuss the effect of cardiotoxicity induced by recombinant human interleukin-11 for injection after chemotherapy in malignant hematopathy patients.Methods 32 patients used rhIL-11 if the count of platelets≤20 × 109/L,or platelets≥20 × 109/L but hemorrhage obviously,during the treatment,rhIL-11 was terminated when the count of platelets≥20 × 109/L and had no change of bleeding.The average time of emerging cardiotoxicity,and the variety of electrocardiogram,color doppler echocardiography,myocardial enzymes,cardiac troponin Ⅰ,brain natriuretic peptide,c-reactive protein and blood pressure by dynamic were observed after use of rhIL-11.Results The median time appearing cardiotoxicity was 3.6 days after using rhIL-11.Arrhythmia was observed by electrocardiogram,especially atrial arrhythmia,atrial fibrillation accounted for 14 cases,atrial premature beats accounted for 12 cases,ventricular premature beat 6 cases,and 18 cases companion of ST-T alteration,echocardiography had no change.Compared with using rhIL-11 formerly,CK,CK-MB,AST,CRP,LDH had significant difference by using rhIL-11(P 0.05),CTnI were all negative,but BNP rose mildly(P 0.05).Blood pressure was(129 ± 10 /76 ± 8) mmHg without using rhIL-11,but the count was(102 ± 11 /71 ± 7) mmHg after using rhIL-11.The change of blood pressure had significant difference before and after treatment(P 0.05).Conclusion Cardiotoxicity which caused by using rhIL-11 could be reversed,has no effect with next chemotherapy,and could be endured by patients.But it needs to give ECG monitoring,reexamine ECG regularly,pays particular attention to symptoms and sign relating to heart,and treats symptoms timely in the process of using rhIL-11." @default.
- W2375052328 created "2016-06-24" @default.
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- W2375052328 date "2014-01-01" @default.
- W2375052328 modified "2023-09-24" @default.
- W2375052328 title "Clinical observation of cardiotoxicity induced by recombinant human interleukin-11 for injection" @default.
- W2375052328 hasPublicationYear "2014" @default.
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