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- W2375060357 abstract "AIM:To establish the methods of isolating and identifying the stem-cell-like hepatocytes from rat pulmonary metastatic hepatocellular carcinoma.METHODS:Rat model of hepatocellular carcinoma with pulmonary metastasis was established by diethylinitrosamine.Hepatocellular carcinoma cells from pulmonary metastasis were proliferated by tissue culture.Side population(SP)cells and non-side population cells were isolated from the cultured cells by Hoechst33342 staining with FACS and were followed by identification for the expression of tumor stem cell markers c-kit and Sca-1 with FACS.Soft agar clone formation assay was performed to determine the tumorigenesis capacity of SP and non-SP cells from hepatocarcinoma cells.RESULTS:The rat model of hepatocellular carcinoma with pulmonary metastasis was established and stable hepatocellular carcinoma cell line was harvested from the model.Side population cells accounted for 0.5% of the total pulmonary metastatic cells.c-kit and Sca-1 were highly expressed on SP cells,with the expression rate of 85% and 75% respectively in SP cells,and 8% and 3% respectively in non-SP cells.Soft agar clone formation rates were 69.90% and 15.25% respectively in SP and non-SP cells,showing that the tumorigenesis capacity of SP cells was higher than that of non-SP cells(P0.01).CONCLUSION:SP pulmonary metastasis hepatocellular carcinoma cells display the features of tumor stem cells." @default.
- W2375060357 created "2016-06-24" @default.
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- W2375060357 date "2009-01-01" @default.
- W2375060357 modified "2023-09-22" @default.
- W2375060357 title "Isolation and identification of side populations from lung metastatic hepatocellular carcinoma in rats" @default.
- W2375060357 hasPublicationYear "2009" @default.
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