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- W2375060590 abstract "Objective To study the subchronic oral toxicity of fuphenthiourae,and to obtain its non-observed adverse-effects level and targeted organs.Methods 80 rats were divided into 4 groups and treated with the test substance added to the basal diet at the doses of 25.00,5.00,1.00 and 0 g/kg for 3 months.The general behavior,body weight,food consumption,food efficiency,7 blood routine tests,11 blood clinical chemistry tests,urine biochemical indexes and routine tests were measured.Organ weights,organ coefficients and histopathological examination were performed.Results During the experiment,no apparent toxic signs appeared in the control and low dose groups.The animals in the high group were inactive 4 weeks after the experiment began,showing piloerection,hair nastiness,stained perineal area,blood secretions from eyes,nose and mouth,decreased body weight gain and reduced food efficiency.At the end of the test,glucose(GLU) of the high and median groups,cholesterol(CHO) of the high dose group,alanine aminotransferase(ALT) of the median group increased, while total bilirubin(TBI)and total protein(TP) of the high dose group descended in the female rats.In the male rats,CHO increased but TP decreased in the high dose group.The macroscopic(gross) examination of visceral organs of treated vs control revealed no diagnostic lesions that could be attributed to test compound administration.Organ coefficients of liver,brain in the high dose group(only in female rats) were higher than those of the control.Organ coefficients of liver in high and median dose groups(only in the males),brain,testicle in high dose group(only in the males) were higher than those of the control.Pathological examination showed that the liver in a few male animals in high dose group had sheet cellular oedema.Conclusion The 90 days non-observed adverse-effect level of the pesticide is 96.44 mg·kg~(-1)·d~(-1) in female rats,and 70.05 mg·kg~(-1)·d~(-1) in male rats,respectively." @default.
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- W2375060590 date "2006-01-01" @default.
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- W2375060590 title "Study on the subchronic oral toxicity of fuphenthiourae" @default.
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