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- W2375063606 abstract "Objective We prospectively investigated the association between alcohol consumption and prostate cancer in the epidemiologic followup study(NHEFS) of the first National Health and Nutrition Examination Survey(NHANES I).Methods There were two cohorts: 1) Cohort I,followed from baseline(1991 to 1995) through 2002,included 5766 men ages 25-74 years(median follow-up-17 years);and 2) Cohort Ⅱ,followed from the first follow-up round for Cohort Ⅰ(2002 to 2004) through 2002,included the 3775 men in CohortⅠfree of prostate cancer in 2002 to 2004(median follow-up9 years).Alcohol consumption was assessed at baseline as usual consumption,and at follow-up as usual consumption and as distant past consumption at the ayes of 25,35,45,and 55.Results There were 254 incident cases of prostate cancer.Consistent with most previous studies,we found no significant associations between usual total alcohol consumption and prostate cancer in Cohorts ⅠorⅡ[p=non significant(NS)],except for a significant inverse association at the heaviest level of drinking in Cohort Ⅱ [relative risk(RR)=0.23,95% confidence interval(CI=0.06-0.95] further study of heavy drinkers in Cohort Ⅱrevealed significant inverse associations between distant past heavy drinking(defined as25 drinks/week) and prostate cancer at age 25(RR = 0.20,95% CI=0.06-0.63),age 35(RR=0.30,95% CI=0.12-0.77),and age 45(RR = 0.39,95% CI = 0.17-0.93),but not at age 55(RR = 0.43,95% CI=0.17-1.10).Conclusion These results suggest that it may be important to consider distant past consumption in etiologic studies of prostate cancer.However,our results were based nn small alcohol numbers and require replication." @default.
- W2375063606 created "2016-06-24" @default.
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- W2375063606 date "2012-01-01" @default.
- W2375063606 modified "2023-09-22" @default.
- W2375063606 title "Alcohol and prostate cancer in the NHANES I:An epidemiologic follow-up study" @default.
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