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- W2375088892 abstract "Objective To study the effect of rutaecarpine on age-related changes in rat arteries.Methods Thirty-two male Wistar rats were randomly divided into 3months old group,12months old group,18months old group,and rutaecarpine treatment group(8in each group).Serum SOD,MDA,GSH levels were measured in different groups.Expressions of eNOS mRNA,eNOS and phosphorylated eNOS protein were detected by RT-PCR and Western blot,respectively.ResultsThe serum MDA level was significantly higher and the expression levels of SOD,GSH,eNOS mRNA,eNOS and phosphorylated eNOSprotein were significantly lower in 18months old group than in 12months old group(P0.05).The serum MDA level was significantly lower and the expression levels of SOD,GSH,eNOS mRNA,eNOS and phosphorylated eNOS protein were significantly higher in rutaecarpine treatment group than in 18months old group(4.96±0.22nmol/mg vs 7.26±0.35nmol/mg,232.07±11.16 U/mg vs 149.88±13.77 U/mg,12.27±1.42μg/mg vs 5.40±0.79μg/mg,1.39±0.15 vs 0.74±0.18,204.67±3.07 vs121.45±2.54,591.44±2.98 vs 469.57±1.79,P0.05).However,no significant difference was found in the above parameters between 3months old group and 12months old group(P0.05).ConclusionRutaecarpine can improve age-related antioxidative function and upregulate eNOS expression in rat arteries,thus playing a vital role in delaying rat vascular aging." @default.
- W2375088892 created "2016-06-24" @default.
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- W2375088892 date "2014-01-01" @default.
- W2375088892 modified "2023-09-23" @default.
- W2375088892 title "Effect of rutaecarpine on age-related changes in rat arteries" @default.
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