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- W2375101303 abstract "Objective To prepare ketoprofen floating microspheres and investigate the drug release in vitro.Methods The ketoprofen floating microspheres were prepared by solvent diffusion-evaporation method using Eudragit L-100.The formulation and process parameters were optimized by orthogonal test.The physicochemical properties of microspheres such as buoyancy,drug loading,encapsulation efficiency and drug release in vitro were investigated as the indexes.Results The prepared microspheres were spherical and smooth in appearance and the particle size distribution was narrow.The yield was 69.15 %.The drug loading and encapsulation efficiency were found to be 38.79% and 50.04%,respectively.More than 52.41% of microspheres were found to float on simulated gastric fluid for 12 h.The cumulative drug release at 12 h was more than 70%.Conclusion This preparation method of floating microspheres is simple and reproducible.This prepared floating microsphere with a spherical cavity cans exhibite prolonged drug release and excellent floatability." @default.
- W2375101303 created "2016-06-24" @default.
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- W2375101303 date "2012-01-01" @default.
- W2375101303 modified "2023-09-25" @default.
- W2375101303 title "Preparation and in vitro release of ketoprofen floating microspheres" @default.
- W2375101303 hasPublicationYear "2012" @default.
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