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- W2375107859 abstract "Objective To investigate the relationship between drug resistance mechanism and nuclear factor kappa B(NF-κB) in acute promyelocytic leukemia(APL). Methods The IC50 value of arsenic trioxide was evaluated by MTT assay. The protein expression of P-glycoprotein(P-gp) was measured by Western blot. The expression of NF-κB p65 were detected in APL cells. Results The IC50 value of arsenic trioxide was (33. 34 ± 1. 28 )μmol/L in APL cells,which decreased to (5. 2 ± 0. 88) μmol/L(P 0. 05) after combination with MG-132. When NF-κB activation was inhibited by MG-132,the protein expression of P-gp had marked changed. The NF-κB p65 protein was expressed only in cytoplasm of APL cells,and expressed in both cytoplasm and cytoblast of APL cells after using arsenic trioxide. Conclusion NF-κB is an important central link of drug resistance mechanism of APL cells. The inhibition of NF-κB activiation may partly reverse the resistance of APL cells against arsenic trioxide." @default.
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- W2375107859 date "2009-01-01" @default.
- W2375107859 modified "2023-09-24" @default.
- W2375107859 title "Relationship between nuclear factor kappa B and drug resistance in acute promyelocytic leukemia" @default.
- W2375107859 hasPublicationYear "2009" @default.
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