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- W2375130711 abstract "Objective To investigate the relationship between Osterix expression and metastatic potential of breast cancer cells as well as to test the effects of Osterix on the promoter activities of MMP-2, MMP-9 and VEGF. Methods Western blot analysis was performed to examine the expression of Osterix in breast cancer cells with various metastatic potential. Luciferase reporter assays were carried out to test the effects of Osterix on MMP-2,MMP-9 and VEGF promoter activities. Results Osterix is highly expressed in metastatic breast cancer cells MDA-MB 361 and MDA-MB 231 and there was no expression of Osterix in poorly metastatic breast cancer cells MCF-7. Furthermore,Osterix was able to significantly enhance MMP-2,MMP-9 and VEGF promoter activities. Conclusions Osterix is highly expressed in metastatic breast cancer cells and it significantly up-regulates the promoter activities of MMP-2,MMP-9 and VEGF. The role of Osterix in bone metastasis of cancers including breast cancer,prostate cancer,etc needs further investigation." @default.
- W2375130711 created "2016-06-24" @default.
- W2375130711 creator A5057640513 @default.
- W2375130711 date "2010-01-01" @default.
- W2375130711 modified "2023-09-28" @default.
- W2375130711 title "Expression of Osterix in Metastatic Breast Cancer Cells and Its Effects on MMP-2,MMP-9 and VEGF Promoter Activities" @default.
- W2375130711 hasPublicationYear "2010" @default.
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