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- W2375133492 abstract "Aim: To study the effects of acetylcholine (ACh) on the delayed neuronal death (DND) of hippocampal neurons after transient cerebral ischemia reperfusion. Methods: A total of 80 rats were allocated into 5 groups at random.Group I, contrast group only being operated on (but not suffering the lesion of medial septum (MS)); Group Ⅱ, only suffering the lesion of MS; Group Ⅲ, the cerebral ischemia reperfusion group; Group Ⅳ, the cerebral ischemia referfusion with shamed lesion of medial septum; Group Ⅴ, the cerebral ischemia referfusion with the lesion of medial septum in advance. In Group Ⅴ,the rats were firstly suffered the lesion of medial septum, then recovered for 15 days.Secondly they were subjected to the 4 vessel occlusion for 20 minutes and reperfused for 72 hours and executed finally. The brains were regularly embedded by paraffin wax,sectioned and stained by Nissle staining, HE staining and Tunel immunohistochemical staining. The hippocampal neurons were counted and evaluated under light microscope. Results: ①The DND occurred only in CA1 regions of groups with the cerebral ischemia and reperfusion (Group Ⅲ,Ⅳ,and Ⅴ), no obvious changes were observed in other regions of hippocampi. ②Compared with Group Ⅲ and Ⅳ,the lesion of the labeled DND neurons of group Ⅴ was obviously alleviated, the difference was significant ( P 0.05). Conclusion: Acetylcholine participates in lesion during the delayed neuronal death in CA1 subfield of hippocampi.The lesion of MS could alleviate the damage of CA1 neurons after ischemia." @default.
- W2375133492 created "2016-06-24" @default.
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- W2375133492 date "2002-01-01" @default.
- W2375133492 modified "2023-09-23" @default.
- W2375133492 title "Experimental study on the effect of MS lesion on delayed neuronal death in hippocampus after cerebral ischemia-reperfusion" @default.
- W2375133492 hasPublicationYear "2002" @default.
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