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- W2375135215 abstract "【Objective】 To analyze changes in coagulation-related parameters in normal pregnant women.【Methods】One hundred and fifty-three normal pregnant women were selected, and blood samples were collected at three trimesters for the detection of concentrations of thrombomodulin(TM), thromboxane B2(TXB2), prothrombin fragment 1+2(F1+2), fibrinopeptide(FPA), D-Dimer(D-D) and plasminogen activator inhibitor-2(PAI-2).Sixty healthy non-pregnant women were served as controls.【Results】The concentrations of FPA, TM, F1+2, PAI-2 and D-D in normal pregnant women were significantly higher than those in the non-pregnant(P 0.01).The concentration of TXB2 was lower in the first trimester(P 0.01) and significantly higher in the third trimester(P 0.01) than the non-pregnant control group.The concentrations of TXB2, PAI-2 and D-D in normal pregnant women were increased with time of gestation(P 0.01).The concentrations of TM and F1+2 were higher in the second and third trimesters than in the first trimester(P 0.01), while there was no significant difference between the second and third trimester(P 0.05).There was no significant change in the concentration of FPA with gestation(P 0.05).ConclusionThe activation of blood platelet, fibrinolysis, damage of vascular endothelial cells and coagulation/anti-coagulation are dyamicly balanced at a higher level in normal pregnancy." @default.
- W2375135215 created "2016-06-24" @default.
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- W2375135215 date "2009-01-01" @default.
- W2375135215 modified "2023-09-26" @default.
- W2375135215 title "Dynamic changes of haemostasis coagulation-related parameters in normal pregnant women" @default.
- W2375135215 hasPublicationYear "2009" @default.
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