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- W2375141505 abstract "BACKGROUND AIM: To study whether N-methyl-N' -nitro-N-nitrosoguanidine(MNNG) could induce the formation of γ H2AX foci in CHL cells. MATERIALS AND METHODS: The cytotoxic effects of different concentrations of MNNG were evaluated by MTT test. The phosphorylation of H2AX was assessed by using immunofluorescent microscopy. RESULTS: MNNG exhibited a dose- and time-dependent cytotoxic effect on CHL cells. MNNG treatment(1 mg/L) significantly increased the ratio of γ H2AX-positive cells and the number of foci/cell at 2, 8, and 24 h. The ratios of cells with over 30 foci/cell were about 56% ,92% and 91% , respectively. CONCLUSION: MNNG could induce the phosphorylation of H2AX in CHL cells in a time-dependent manner." @default.
- W2375141505 created "2016-06-24" @default.
- W2375141505 creator A5043568223 @default.
- W2375141505 date "2006-01-01" @default.
- W2375141505 modified "2023-09-28" @default.
- W2375141505 title "N-methyl-N'-nitro-N-nitrosoguanidine Induces the Phosphorylation of Histone H2AX in CHL Cells" @default.
- W2375141505 hasPublicationYear "2006" @default.
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