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- W2375168852 abstract "Objective To discuss the relationship between vascular endothelial growth factor gene-460C/T polymorphism and non-cardiac gastric cancer.Methods The study population included 159 gastric cancer patients and 162 cancer-free control subjects.The SNP in the VEGF-promoter was analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Genotype frequencies were compared between patients and controls,and the association of genotypes with clinicopathological features was studied.Results The frequencies of CC,CT and TT genotypes were 3.2%,35.2% and 61.6 % in the gastric cancer group respectively,and 8.0%,48.2% and 43.8% in the control group respectively.VEGF genotype distribution in gastric cancer patients was significantly different than that in controls(χ2=11.454,P=0.003).The frequency of TT genotype was significantly higher in the gastric cancer patients than that in the controls.The risk of gastric cancer for subjects with TT genotype was 3.58 times(OR=0.279,95%CI: 0.095~0.817) that of those with CC genotype,and 1.9 times(OR=0.52,95%CI: 0.329~0.824) that of those with TC genotype.Further analysis also revealed that subjects carrying a T allele had a 1.8 times higher risk of gastric cancer than those with a C allele(OR =0.55,95% CI: 0.387~0.792).No statistically significant differences in clinical stage or grade were found.Conclusion The T allele for the VEGF-460 gene polymorphism is a suitable genetic marker of gastric cancer,but can not be used in the prediction for the prognosis of patients." @default.
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- W2375168852 date "2012-01-01" @default.
- W2375168852 modified "2023-09-26" @default.
- W2375168852 title "Relationship between vascular endothelial growth factor gene-460C/T polymorphism and non-cardiac gastric cancer" @default.
- W2375168852 hasPublicationYear "2012" @default.
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