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- W2375171828 abstract "Objective To investigate the effects of breviscapine on the lung injury induced by hepatic ischemia-reperfusion in rats.Methods 40 Wister female rats were randomly divided into four group:sham group,model group,low-dose breviscapine group[10 mg/(kg·d)]and high-dose breviscapine group[20 mg/(kg·d)],n = 10. Intraperitoneal injection saline or breviscapine for 7 days,then the model of lung injury were bulit by hepatic ischemia-reperfusion induced.The levels of MDA,total antioxidant capacity(T-AOC) were measured in Lung tissue,pulmonary morphology was determined.Results Compared with the sham group,the MDA content were increased and the T-AOC activity was decreased in model group(P0.05);Compared with model group,T-AOC was higher while MDA was lower in low and high-dose breviscapine group(P0.05).Pathology examination revealed that the alveolus architecture was destroyed with interstitial thickening and neutrophil infiltration in model group.Lung injury were alleviated in low and high-dose breviscapine group.Conclusion Breviscapine has a protective effect on lung injury induced by hepatic ischemia-reperfusion.One of the mechanisms of the pulmonary protection may be related to the antioxidative function." @default.
- W2375171828 created "2016-06-24" @default.
- W2375171828 creator A5017460022 @default.
- W2375171828 date "2012-01-01" @default.
- W2375171828 modified "2023-09-23" @default.
- W2375171828 title "Effects of breviscapine on lung injury induced by hepatic ischemia-reperfusion in rats" @default.
- W2375171828 hasPublicationYear "2012" @default.
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