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- W2375176293 abstract "Aim To observe the cross-resistance of the cell subline resisting to DDP (L1210/DDP) and its possible mechanism. Methods Drug sensitivity was determined by dye exclusion assay. The concentration of Pt and glutathionin, activity of glutathione transferase and cross-link of DNA were compared using a non-flare atomic absorption spectrometer,a circulation method of glutathione transferase and alkali washing with micropore film. Results L1210/DDP was cross-resistant to carboplatin, partly resistant to mitomycin and thiotepa, but sensitive to arabinosylcytosin and 5-fluorouracil. The Pt concentration in L1210/DDP was significant lower than that in L1210. The concentration of glutathionin as well as the activity of glutathione transferase in the subline was markedly higher than those of the maternal line. The cross-link of DNA in L1210 under DDP treatment was lower than that in the maternal line. Conclusion L1210/DDP was resistant to DDP and carboplatin, and its possible mechanism might be related to reduced Pt concentration, elevated the concentration of glutathionin and the activity of glutathione transferase, and decreasing crosslink of DNA." @default.
- W2375176293 created "2016-06-24" @default.
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- W2375176293 date "2008-01-01" @default.
- W2375176293 modified "2023-09-25" @default.
- W2375176293 title "Cross-resistance of L1210/DDP Cell and its Possible Mechanism①" @default.
- W2375176293 hasPublicationYear "2008" @default.
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