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- W2375181657 abstract "Objective To investigate the anti-apoptotic effect of interleukin-6 (IL-6) with differ- ent concentrations on annulus fibrosus cell apoptosis in vitro induced by IL-1β.Methods The cultured annulus fibrosus cells were incubated with 10μg/L IL-1βfor 3 days to induce apoptosis.During the pro- cedure,10 or 100μg/L IL-6 was separately added to the culture medium to affect apoptosis.By using flow cytometry (FCM),the apoptosis of the cells stained with Annexin-V and Propidium Iodide (PI) was assayed,and the function of Caspase-9 in the cells detected after Caspase-9 activity staining.Results Co- culture with IL-1βresult in a significant great percentage of apoptosis compared with without IL-1 [(2.67±1.08)% versus (20.37±1.57)%,(mean±SEM)].With intervention of 10μg/L IL-6,IL-1 induced apoptosis percentage reduced to (18.17±4.68)% (P＜0.05).Exposure to 100μg/L IL-6 can reduce the percentage of apoptosis to (9.42±1.27)% (P＜0.01).On the other hand,the two concen- tration of IL-6 can reduce percentage of Caspase-9+ cells from (19.40±0.98)% (after co-cultured with IL-1) to (15.13±1.45)% (P＜0.01) and (10.17±2.50)% (P＜0.01) respectively.Conclusion The data demonstrate a significant reduction in the percentage of apoptotic annulus fibrosns cells,when exposed to 10μg/L and 100μg/L IL-6.And percentage of Caspase-9+ ceils also reduced when affected by IL-6.These findings suggest IL-6 can partly protect annulus fibrosns cells from IL-1 induced apopto- sis.And the protection may be related with inhibition of Caspase-9 activity." @default.
- W2375181657 created "2016-06-24" @default.
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- W2375181657 date "2006-01-01" @default.
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- W2375181657 title "Interleukin-6 inhibiting interleukin-1βinduced apoptosis of annulus fibrosus cells in vitro" @default.
- W2375181657 hasPublicationYear "2006" @default.
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