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- W2375194617 abstract "Objective To explore the appropriate method of laser treatment for melasma.Methods Clinical trials and animal experiments were carried respectively,using a 1064nm Q-switch Nd: YAG laser with large spot and low fluence.The efficacy and safety of this treatment were estimated by visual,melanin content index(MCI),confocal laser scanning microscopy(CLSM) and histological analyses.Results The results of clinical trials showed: after treatment,eight cases were basically cured,25 cases were markedly effective,12 cases were improved,one case was uneffective,and with an effective rate was 73.33%.MCI decreased significantly compared with that before treatment(P0.05).The CLSM images showed a drastic decreasing in the reflection from epidermal-basal keratinocytes,but dendritic melanocytes became visible.Animal experiments showed: after treatment,skin pigmentation in guinea pigs was completely cleared,and MCI decreased significantly(P0.01).CLSM and pathological images showed melanin granules and melanotytes around the hair follicles and basal layer of epidermal were significantly reduced.But through a four-week follow-up,all skins developed rebound hyperpigmentation,and MCI was significantly higher,but lower than that before treatment(P0.05).CLSM images showed increased epidermal melanin particles and MC,and the staining intensity significantly increased in basal layers.Control group had no significant changes before and after treatment.Conclusion Treatment with lager spot size and low fluence of the 1064nm Q-switch Nd: YAG laser give an effective short-term relief of melasma,but with a high risk of recurrence." @default.
- W2375194617 created "2016-06-24" @default.
- W2375194617 creator A5072829321 @default.
- W2375194617 date "2011-01-01" @default.
- W2375194617 modified "2023-09-23" @default.
- W2375194617 title "Effect of Q-switch Nd:YAG Laser with Large Spot and Low Fluence for the Treatment of Melasma" @default.
- W2375194617 hasPublicationYear "2011" @default.
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