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- W2375201390 abstract "Objective To analyze the prognosis of Cushing's disease via transsphenoidal surgery retrospectively and to explore the surgical technique and factors affecting the outcome. Methods Fifty-four patients with Cushing's disease receiving transsphenoidal surgery between Jan.2001 and Dec. 2006, were reviewed. Among them, there were 39 microadenomas, 3 macroadenomas. Twelve cases which had normal image on the MRI scan were diagnosed by Dexamethasone test or/and bilateral inferior petrosal sinus sampling. During the operation, selective resection of adenoma was performed in 38 cases and part or hemi-hypophysectomy in 16 cases. The pathological finding confirmed the ACTH secreting adenoma in forty-nine cases, and pituitary corticotroph hyperplasia in 5 cases. The criteria of remission of patients were a cortisol value of 5 ng/ml or less on postoperative day 1 or day 2. Results The total remission rate was 75.9%. The rate was significantly higher in MRI positive adenomas than MRI negative ones; patients receiving intraoperative selective adenomectomy had a higher remission rate than those receiving hemi-hypophysectomy did; and remission rate was higher in ACTH secreting adenoma than in pituitary corticotroph hyperplasia (P=0.033, 0.035, and 0.01 respectively). There were 2 recurrent cases during the follow-up period. Conclusions Transsphenoidal surgery should be performed on Cushing' s disease, even if negative findings on the MRI scan. The prognosis is associated with the findings on preoperative imaging, intraoperative inspection and pathology." @default.
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- W2375201390 date "2008-01-01" @default.
- W2375201390 modified "2023-09-23" @default.
- W2375201390 title "The treatment of Cushing's disease via transsphenoidal surgery" @default.
- W2375201390 hasPublicationYear "2008" @default.
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