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- W2375202175 abstract "Purpose:To understand the expression level on esophageal carcinoma cell multidrug resistsnce and cyclin-control factors which affect survival in the patient.Methods:Immunohistochemistry was used to examine the expression level on the esophageal carcinoma cell P-glycoprotein(P-gp) and cyclin control factor(P27) in the 104 cases surgical specimens which had follow-up data,and clinical pathologic analysis was also done.Results:P-gp negative expression was found in 70/104(67.3%) cases with esophageal carcinoma and positive expression in 34 cases.Among these low-grade expression was 6 cases(5.7%);medium expression was 18 cases(17.3%); high expression was 10 cases(9.6%).P27 negative expression was found in 34/104(32.7%)cases with esophageal carcinoma and positive expression in 70 cases,among these low-grade expression was seen 7 cases(6.7%);medium expression in 42 cases(40.4%);high expression in 21 cases(20.2%).P-gp positive expression was found in 10 cases(17.5%) in the three years survival group,and those who died within 3 yrs had P-gp positive expression(24 cases,53.3%).Comparing of the two groups showed statistical significance(P0.0001).P-gp over expression was related to the cancer cell biological malignant behavior with regard to death-rate.The P27 positive expression was 44 cases(75.8%) in the 3 year survival stage group,and the patients who died within three years group,the P27 expression was positive in 26 cases(56.5%)(P0.05).P27 over expression was not related to the cancer cell biological malignant behavior as regards death rate.Tumor differentiation degree: Comparism of the surviving group with the non-survivors had a statistical significance(P0.05).Tumor invasion deep degree: In survival of over three years group whole lamina was invaded in 31cases(53.4%) only.Whereas,in the non-survivors group the whole lamina was invaded in 38 cases(82.6%),(P0.01).The lymph node metastasis in survival group as compared to non-survivors had a statistical significance(P0.05),as well as clinical stage,(P0.05).Conclusions:The P-gp over expression was positively related to cancer cell biological malignant behavior and death rate.The P27 over expression was not related to the cancer cell biological malignant behavior and death rate.It could provide a reference basis for selecting the chemotherapy protoeal. The tumor differentiation degree,invasion degree,lymph node metastasis,and its clinical stage were all important factors for patient survival." @default.
- W2375202175 created "2016-06-24" @default.
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- W2375202175 date "2005-01-01" @default.
- W2375202175 modified "2023-09-27" @default.
- W2375202175 title "Study on the expression level of esophageal carcinoma P-gp and P27 and affecting survival in the patient" @default.
- W2375202175 hasPublicationYear "2005" @default.
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