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- W2375229690 abstract "OBJECTIVE A Caco-2 monolayer cell model was established to examine the effect of the aqueous extract of Chinese galls(AECG) on α-glucosidase(maltase and sucrose) activity and underlying mechanism.METHODS The effect of AECG on α-glucosidase activity was measured using the enzyme-inhibition model and Caco-2 monolayer cells.In particular,the sucrose and maltase activity as well as glucose uptake and transport were determined.RESULTS The data revealed that AECG could inhibite the α-glucosidase on enzyme-inhibition model and Caco-2 monolayer cells.Furthermore,AECG treatment moderately but significantly suppressed the uptake and transport of glucose.CONCLUSION The hypoglycemic effect of Chinese galls may be associated with its inhibitory effect against of disaccharidase(such as sucrose and maltase) possibly through inhibition of the α-glucosidase enzyme as well as the uptake and transport of glucose.Moreover,it has great value in the Caco-2 monolayer model in the practical screening of potential anti-diabetic drug candidates." @default.
- W2375229690 created "2016-06-24" @default.
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- W2375229690 date "2011-01-01" @default.
- W2375229690 modified "2023-09-28" @default.
- W2375229690 title "Hypoglycemic mechanism of the aqueous extracts of Chinese galls in monolayer Caco-2 cells" @default.
- W2375229690 hasPublicationYear "2011" @default.
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