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- W2375243414 abstract "Objective: To investigate the molecular biological mechanism, on genomic level, of using Wusan Granule in treating Lewis lung carcinoma. Methods: The total RNAs were isolated from carcinoma tissue of two groups, treated or un-treated by Wusan Granule. They were purified, both mRNA were reversely transcribed to the cDNAs and labelled with fluorescence to prepare the cDNA probe, which was hybridized with mouse MGEC-20S gene chip to screen the different expressed genes between the two groups. Results; There were 45 different expressed genes between the two groups. As compared with the group un-treated with Wusan Granule, in the treated group, the tumor infiltration and metastasis related gene expressions were down-regulated and the tumor cell apoptosis related gene expression up-regulated. Conclusion: The cDNA microarray technique is a high-throughout approach to screen the Wusan Granule anti-tumor related target genes, which provides new pathway and advanced biological means for studying of the scientific entity of Chinese herbal medicine in treating tumor." @default.
- W2375243414 created "2016-06-24" @default.
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- W2375243414 date "2003-01-01" @default.
- W2375243414 modified "2023-09-28" @default.
- W2375243414 title "Analysis of Anti-Lewis Lung Carcinoma Related Target-gene in Tumor Tissue Treated by Wusan Granule by cDNA Microarray" @default.
- W2375243414 hasPublicationYear "2003" @default.
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