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- W2375245887 abstract "Objective To investigate the pharmacokinetics of compound Lutin in rats. Methods The high performance liquid chromatography (HPLC) method was used to determine Lutin and aspirin in rat plasma. The analytical column was a CLC-ODS (5 μm, 6 mm×150 mm). The mobile phase was a mixture of acetonitrile, methanol, and phosphoric acid. Detection was performed at UV230 nm. Atomic absorption spectrophotometry (AAS) was used to determine the plasma concentration of Mg 2+ . Results The detected minimum concentration of Lutin was 0.748 μg/ml in rat plasma, and the average recovery was 95.3% - 97.8%. The detected minimum concentration of aspirin was 0.222 μg/ml in rat plasma, and the average recovery was 94.2% - 6.6%. Conclusion HPLC method with better specificity and high degree of precision and recovery ratio could detect the plasma concentrations of Lutin and aspirin at the same time. The results suggest that the pharmacokinetics of each component of compound Lutin accord with the two-compartment model." @default.
- W2375245887 created "2016-06-24" @default.
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- W2375245887 date "2004-01-01" @default.
- W2375245887 modified "2023-09-23" @default.
- W2375245887 title "Pharmacokinetic study of compound Lutin in rats" @default.
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