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- W2375276616 abstract "Objectives: To explore the possible mechanism of DMPA induced abnormal uterine bleeding.Methods: Fifty-two volunteers were recruited to use 150 mg DMPA for contraception for one year.At the 5th day of menstrual cycle before using DMPA,and at the end of 12 months of using the drug,serum levels of estradiol and progestogen were measured.Menstrual changes were observed in one year.Curettage was performed in six volunteers who had long-term abnormal uterine bleeding.Ultrastructure of endometrium was observed by electronic microscope.Results: There was no significant difference in serum levels of estradiol and progestogen before and after using DMPA(P0.05).The levels of estradiol and progestogen were similar in three groups-normal uterine bleeding group,abnormal uterine bleeding group and amenorrhea group.Electronic microscopic observation showed that the morphology of endometrial epithelioid cell and glandular cell was slightly abnormal in the patients with abnormal uterine bleeding.There were no glucogen particles in the lumen of gland.The change of stromal cells was relevant to the duration of the drug use.In early stage the morphology of stromal cells was slightly abnormal,while in late stage,a great number of stromal cells showed apoptosis.Capillary vessels were seldom seen. Conclusion: Abnormal uterine bleeding in DMPA users was relevant to low estradiol level,but low estradiol level was not the single decisive factor." @default.
- W2375276616 created "2016-06-24" @default.
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- W2375276616 date "2008-01-01" @default.
- W2375276616 modified "2023-09-23" @default.
- W2375276616 title "DMPA induced abnormal uterine bleeding: changes of sex hormone levels and endometrial ultrastructure" @default.
- W2375276616 hasPublicationYear "2008" @default.
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