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- W2375290498 abstract "AIM To explore putative effects of sterigmatocystin (ST) on immunoregulatory function. METHODS BALB/c mice were randomly divided into normal control, solvent control and ST 3, 30, 300 and 3000 μg·kg-1 groups. The mice were sacrificed 24 h after ST was ip given and thymus and spleen were taken out. The percentages of CD4+ and CD8+ as well as transcription factor Foxp3+ regulatory T lymphocytes in thymus and spleen were determined with flow cytometric (FCM) method. The changes in number of Foxp3+ regulatory T cells were measured with immunohistochemical staining. Foxp3 expression at protein and mRNA level in thymus and spleen were respectively analyzed with Western blotting and reverse transcription polymerase chain reaction (RT-PCR) methods. RESULTS FCM results showed that there were no significant differences in the percentages of CD4+, CD8+ and Foxp3+ T in thymus and spleen between normal control and solvent control groups. Compared with control groups, the percentage of thymus CD8+ T cell in ST 3 μg·kg-1 group was significantly decreased, while that of splenic CD4+ and CD8+ T cells in both ST 3 and 30 μg·kg-1 groups were all significantly increased. No significant differences in the percentages of CD4+ or CD8+ T cells were found between ST 300 and 3000 μg·kg-1 groups with control groups in thymus and spleen. At the same time, the results revealed that from 3 to 3000 μg·kg-1, ST could significantly increase precentages and numbers of Foxp3+ T lymphocytes as well as expression of Foxp3 at both protein and mRNA levels in thymus and spleen dose-effectively. CONCLUSION ST exposure could induce increase in Foxp3+ regulatory T lymphocytes in lymphatic organ, thus may affect the immune tolerance of host." @default.
- W2375290498 created "2016-06-24" @default.
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- W2375290498 date "2009-01-01" @default.
- W2375290498 modified "2023-09-25" @default.
- W2375290498 title "Effect of sterigmatocystin on transcription factor Foxp3~+ regulatory T lymphocytes of thymus and spleen in mice" @default.
- W2375290498 hasPublicationYear "2009" @default.
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