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- W2375297989 abstract "Objective To evaluate the clinical significance of neutrophil gelatinase associated lipocalin(NGAL),also called human neutrophil lipocalin(HNL),in differential diagnosis of acute bacterial and viral infections.Methods A double antibody sandwich ELISA method for NGAL / HNL was developed.A randomized single blind trial was performed in 250 patients with simple acute infectious diseases(including 150 cases of bacterial infection and 100 cases of viral infection) who visited the 208th Hospital of PLA in China from April 2010 to March 2011.The NGAL / HNL contents in sera of patients were determined by the developed method,based on which the clinical significance of NGAL / HNL in differential diagnosis of acute bacterial and viral infections was evaluated by comparing the determination results with the practical diagnosis in clinic,routine blood test and determination result of C-reactive protein(CRP).Results The NGAL / HNL,CRP and WBC contents as well as percentage of neutrophil(NEUT) in sera of patients with bacterial infection were significantly higher than those with viral infection(each P 0.01).The sensitivity and specificity of determination of NGAL / HNL content in sera for differential diagnosis of acute bacterial and viral infections were 84.67% and 95% respectively,while the positive and negative predictive values as well as accuracy were higher than those of tests for CRP,WBC,NEUT and percentage of NEUT.Conclusion NGAL / HNL showed high sensitivity and specificity in differential diagnosis of acute bacterial and viral infections as compared with other methods such as routine blood test and determination of CRP,indicating a higher capability in differential diagnosis." @default.
- W2375297989 created "2016-06-24" @default.
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- W2375297989 date "2012-01-01" @default.
- W2375297989 modified "2023-09-27" @default.
- W2375297989 title "Clinical significance of neutrophil gelatinase associated lipocalin / human neutrophil lipocalin in differential diagnosis of acute bacterial and viral infections" @default.
- W2375297989 hasPublicationYear "2012" @default.
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