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- W2375304294 abstract "AIM: To investigate the urinary protein (UP) excretion in rats suffering from renal ischemia-reperfusion (I-R) and effect of nitric oxide on it. METHODS: SD rats were used to establish the renal I-R model. Sodium nitroprusside (SNP), N ω-nitro-L-arginine (L-NNA) and aminoguanidine (AG) were used to determine the effect of nitric oxide on UP excretion under renal I-R. Quantitative analysis of UP was made by chromatometry. UP species were separated by SDS-PAGE. RESULTS: Renal I-R caused significant increase in UP ( P0.01 ). Compared with sham control, urinary proteins larger than albumin (66 kD) was found in I-R group. The increase in NO production after renal I-R was also observed and was closely correlated with the change of UP ( r=0.704, P0.01 ). SNP increased UP excretion, AG and L-NNA decreased it in I-R rats. CONCLUSION: Renal I-R led to the increase in UP excretion. NO seems to play an important role in the UP excretion on rats suffering from renal I-R." @default.
- W2375304294 created "2016-06-24" @default.
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- W2375304294 date "2001-01-01" @default.
- W2375304294 modified "2023-09-23" @default.
- W2375304294 title "Effect of nitric oxide on proteinuria excretion in rats suffering from renal ischemia-reperfusion" @default.
- W2375304294 hasPublicationYear "2001" @default.
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