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- W2375306788 abstract "Objective:To observe the changes of pulmonary function and the relations among them and CR1,CD59 and other index. Methods:Pulmonary function in 80 patients with rheumatoid arthritis were determined and compared with normal control group.The correlation between pulmonary function and CR1,CD59 and other index(age,course of disease,accumulate points of symptoms,accu- mulate points of life quality and index of experiment)were analyzed.Results:IC,MVV,FVC,FEV1,FEF25,FEF50,FEF75,PEF of patients with rheumatoid arthritis were lower than those of normal control group(P0.05).Correlation analysis showed that there was a positive correlation between IC and C3(P0.05).There were negative correlations between MVV and age,time of walking 15m,α1-AGP,CRP and ESR(P0.05).There were negative correlations between FVC and time of walking 15m,IgA,CA,α1-AGP and CRP(P0.05).There were negative correlations between FEV1 and accumulate points of joint pain,accumulate points of physi- ological function,IgA,C4,α1-AGP,CRP(P0.05).There were negative correlations between FEV1/FVC and course of disease,ac- cumulate points of joint swelling,RF(P0.05).There were negative correlations between FEF25 and age,accumulate points of joint swelling,time of walking 15m,accumulate points of physiological function and CRP(P0.05).There were negative correlations be- tween FEFS0 and age,accumulate points of joint pain,time of walking 15m,accumulate points of physiological function,C4,CRP and ESR(P0.05).And there were positive correlations between FEF50 and CR1 and CD59.There were negative correlations between FEF75 and accumulate points of joint pain,time of walking 15m,RF,α1-AGP,CRP and ESR(P0.05).And there were positive correlations between FEF75 and CD59.There were negative correlations between PEF and accumulate points of joint pain,time of walking 15m,accumulate points of physiological function and CRP(P0.05).Conclusion:Many pulmonary function parameters were significantly decreased in patients with rheumatoid arthritis compared with normal control group.The most characteristic pulmonary function change was the decrease of ventilation capacity.The high ratio of small airway's obstruction and decrease of lung capacity can also be found.In addition,the changes of pulmonary function correlated with the deficiency of CR1,CD59 and unusual activation of complement system.They also nearly correlated with patients' condition and activities of disease." @default.
- W2375306788 created "2016-06-24" @default.
- W2375306788 creator A5068923736 @default.
- W2375306788 date "2007-01-01" @default.
- W2375306788 modified "2023-09-24" @default.
- W2375306788 title "Changes of Pulmonary Function in Patients with Rheumatoid Arthritis and Correlation Study between Them and CR1 and CD59" @default.
- W2375306788 hasPublicationYear "2007" @default.
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