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- W2375331399 abstract "Objective To determine the effect of tranexamic acid on perioperative blood loss in patients who underwent transurethral resection of the prostate(TURP),as well as its safety. Methods A double blind randomized control trial was conducted from January 2012 to February 2013. In this trial,30 patients of the tranexamic acid group(T group),between age of 55-85 years,underwent TURP and received 1 g of tranexamic acid in 200 m L normal saline after induction of anesthesia and 30 patients of the control group(C group) received a placebo(normal saline only). The medicine dripping speed ranged 20-40 drops / minute. The amount of blood loss was measured during the operation and at 4 h and 24 h postoperatively and the difference between the two groups was analyzed. Coagulation profiles,including prothrombin time,thrombin time and fibrinogen level,were measured preoperatively and 4 h postoperatively. Any signs of thromboembolic event especially in the lower limbs or within 7 days were noted. Results The blood losses during operation and 4 h postoperation were(102. 0 ± 11. 4) m L and(61. 9 ± 6. 1) m L,respectively in the T group and(303. 6 ± 24. 8) m L and(84. 8 ±15. 2) m L,respectively in the C group. The values were significantly lower in the T group compared to those in the C group(P 0. 05). However,there was no significant difference at 24 h postoperative blood loss between the groups. The coagulation profiles in the two groups were statistically not relevant. There was no evidence of deep vein thrombosis in the lower limbs or in both groups. Conclusion Tranexamic acid can reduce intraoperative blood loss during TURP without increasing the risk of thrombosis." @default.
- W2375331399 created "2016-06-24" @default.
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- W2375331399 date "2014-01-01" @default.
- W2375331399 modified "2023-09-23" @default.
- W2375331399 title "Effect of tranexamic acid on perioperative blood loss during transurethral resection of prostate" @default.
- W2375331399 hasPublicationYear "2014" @default.
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