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- W2375355061 abstract "Objective:To study the correlation between AGTR1 polymorphism and autoantibodies against AT1 receptor(AT1-AAs) in patients with essential hypertension. Methods:394 patients with essential hypertension admitted to our hospital were randomly selected and were divided into the autoantibody positive and negative group.The AT1-AAs were detected by ELISA.Genomic DNA was extracted from erythrocytes by the blood DNA extraction kit.Single-nucleotide polymorphisms were detected by ligase detection reaction,including rs1492078,rs12721226,rs1064533,rs5186 and rs3804005.The frequency of genotyoes and haplotype were analyzed. Results:The frequencies of all genotyoes were not different between the AT1-AAs positive group and negative group(P0.05),but the significant difference was found on the frequencies of haplotypes and (respectively P=0.032,0.014) between two groups. Conclusion:The results show that there is a certain correlation between AGTR1 polymorphism and the AT1-AAs production in patients with essential hypertension." @default.
- W2375355061 created "2016-06-24" @default.
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- W2375355061 date "2011-01-01" @default.
- W2375355061 modified "2023-09-25" @default.
- W2375355061 title "Analysis about AGTR1 polymorphism,haplotype and autoantibodies against AT1 receptor in patients with essential hypertension" @default.
- W2375355061 hasPublicationYear "2011" @default.
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