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• W2375358346 abstract "Objective:To elucidate the changes of cytokines in patients with severe congestive heart failure (CHF) and their response to valsartan. Methods:The subjects were divided into investigation group with severe CHF ( n =80) and healthy control group ( n =40). Plasma levels of tumor nerosis factor α(TNF α), interfon leukocyte 1 (IL 1) and interfon leukocyte 6 (IL 6) were measured through radioimmunoassay. The investigation group was further subdivided into either conventional or conventional plus valsartan groups. Cytokines were rechecked one month later. Results:The plasma levels of all the three kinds of cytokines of CHF patients were higher than those of the control group. The levels of cytokines increased with the severity of heart failure ( P 0.01 ). There was no difference of cytokines in patients with the same severity of heart failure from different causes ( P 0.05 ). Valsartan improved cardiac function and lowered the plasma levels of all the three kinds of cytokines ( P 0.01 ). Conclusion:Cytokines play an important role in the development of heart failure and this role has nothing to do with the basic diseases.Valsartan can improve cardiac function as well as lower the levels of cytokines." @default.
• W2375358346 created "2016-06-24" @default.
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• W2375358346 date "2002-01-01" @default.
• W2375358346 modified "2023-09-25" @default.
• W2375358346 title "Changes of cytokines in severe heart failure and effect of valsartan on them" @default.
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