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- W2375361960 abstract "Objective To observe the effect of doxapram on attenuating the degree of somnolence caused by fentanyl + ketamine + midazolam patient controlled intravenous analgesia(PCIA) in patients with refractory cancer pain.Methods Twenty patients with refractory cancer pain were randomly assigned to begin PCIA with two different formulas: one was fentanyl 2.0 mg+ketamine 200 mg+midazolam 10 mg in 200 mL pack(formula C),and the other was also given doxapram 200 mg(formula D).After the first dose was finished,the patients were switched to use the other formula.The analgesia effect,degree of sedation,quality of life(QOL) scores,blood gas and side-effects were compared between different formulas.Results The analgesic effects were satisfactory in all patients,and the visual analogue scale(VAS) scores were not significantly different with the treatments of either formula(P0.05).Five patients had somnolence and 1 had respiratory depression during the treatment with formula D,and the numbers were 13 and 6 when they were treated with formula C,respectively(P0.05).QOL score was significantly higher when patients were treated with formula D(39.35±8.79) compared with that in patients treated with formula C(31.45±9.42,P0.01) 2 h after PCIA.The Ph value,pressure of arterial oxygen(paO2),and base excess(BE) with formula D were significantly higher than those with formula C(P0.05),and the pressure of arterial carbon dioxide(paCO2) was significantly lower than that with formula C(37.48±2.52 vs.42.51±3.72,P0.01).The incidences of hypersomnia and respiratory inhibition with formula D were significantly lower than those with formular C(P0.05).Conclusion Addition of Doxapram for PCIA can effectively attenuate somnolence during intravenous analgesia for refractory cancer pain,and can improve the patients' quality of life." @default.
- W2375361960 created "2016-06-24" @default.
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- W2375361960 date "2011-01-01" @default.
- W2375361960 modified "2023-09-28" @default.
- W2375361960 title "Doxapram attenuates somnolence caused by intravenous analgesia in patients with refractory cancer pain" @default.
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