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- W2375366369 abstract "Objective To investigate the effects of endothelin|1(ET|1) on the L|type Ca+{2+} channel current(I-{Ca|L}). Methods Using the whole cell patch clamp technique in isolated guinea pig ventricular myocytes during both normal Tyrode solution and imitative ischemic condition. Results In normal Tyrode solution, the application of ET|1(5, 10, 50 nmol/L) increased obviously the peaks of I-{Ca|L} by 25 55%±3 65%, 44 98%±1 68% and 72 0%±45 5% compared with the controlled group(P0 05, respectively). But ET|1 did not produce notable changes on I-{Ca|L} under imitative acute ischemia. There was no any significant changes on maximum active voltage and I-{Ca|L} I|V relationship curve. Conclusion The results suggest that the ET|1 has a remarkable enhancement on I-{Ca|L} in isolated guinea ventricular myocytes under normal Tyrode solution, and do not show obvious changes on I-{Ca|L} under imitative acute ischemia.;" @default.
- W2375366369 created "2016-06-24" @default.
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- W2375366369 date "2003-01-01" @default.
- W2375366369 modified "2023-09-23" @default.
- W2375366369 title "Effects of Endothelin-1 on L-type Calcium Current in Guinea Pig Ventricular Myocytes during Acute Ischemia" @default.
- W2375366369 hasPublicationYear "2003" @default.
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