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- W2375367056 abstract "Objective To investigate the effect of matrix metalloproteinase-7(MMP-7)and vascular endothelial growth factor-A(VEGF-A)expression on tumor invasion and metastasis in colorectal carcinoma.Methods The expression of MMP-7 and VEGF-A was detected in 86 colorectal carcinomas and 10 normal colorectal tissues by immunohistochemical methods.Results The positive expression rate of MMP-7 and VEGF-A in 86 colorectal tissue sampleswas 65.1% and 50% respectively,which was statistically higher than that in control group.MMP-7 and VEGF-A expression was correlated to lymph node metastasis,differentiation and Dukes grade of carcinoma(P0.05).The overexpression of VEGF-A was closely related to the positive expression of MMP-7(P0.01).Conclusion The overexpression of MMP-7 and VEGF-A is closely related to tumor invasion and metastasis,and they might be used as important prognosis indicators." @default.
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- W2375367056 date "2007-01-01" @default.
- W2375367056 modified "2023-09-23" @default.
- W2375367056 title "Effect of matrix metalloproteinase-7 and vascular endothelial growth factor-A expression on tumor invasion and metastasis in colorectal carcinoma" @default.
- W2375367056 hasPublicationYear "2007" @default.
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