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- W2375369559 abstract "OBJECTIVE To prepare sustained-release capsules Loaded with silymarin solid dispersions and to evaluate its releasing features in vitro.METHODS The ratio of SM/carrier was selected by comparing dissolution and solubilization efficiency. The formulation was designed by orthogonal method. HPMC was the matrix,MCC was used as additive.RESULTS The SM/poloxamer ratio was 1∶3 using poloxamer as carrier. The optimized prescription was A3B2C1,HPMC (K15M) as hydrophilic gel matrices material(20%); MCC-Solid Dispersions(1∶3). CONCLUSION The capsules have desirable sustain-release capability. The formulation and technique are simple and can be applicable for production." @default.
- W2375369559 created "2016-06-24" @default.
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- W2375369559 date "2008-01-01" @default.
- W2375369559 modified "2023-09-28" @default.
- W2375369559 title "Preparation of sustained-release capsules loaded with silymarin solid dispersions" @default.
- W2375369559 hasPublicationYear "2008" @default.
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