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- W2375376576 abstract "Objective To improve the understanding of the etiology,diagnosis and treatment of hepatic veno-occlusive disease(HVOD),we analyze the clinical features of HVOD caused by traditional Chinese medicine(TCM) containing pyrrolizidine alkaloids(PAs).Methods Retrospectively analyze the clinical data of 10 cases with HVOD caused by TCM reported from 1980 to 2006 in China,and that of 3 cases with HVOD caused by TCM in PUMCH,and review the related literatures.Results 11 of the 13 cases(84.6%) were caused by gynura root,which were dosed from 150 g to 1 800 g(average 582 g),lasted for over 10 days to 4 months(average 42.5 days).One of the 13 cases was caused by qianliguang,and one was caused by tea-thirsty.The main symptoms were abdominal distention and pain,ascites,hepatomegaly and jaundice.Liver function may be abnormal mand GGT and ALP mostly increased.The imaging features were slow flow of portal vein by ultrasound and patchy fatty-liver liked changes by CT.9 of the 13 cases were diagnosed by pathology,and 4 were diagnosed according to clinical features.2 cases got improvement by medical treatment,2 got liver-transplantation,and 5 cases died.Conclusion TCM containing pyrrolizidine alkaloids is an important cause of HVOD,and it should by used with cautious.Early diagnosis is valuable to improve prognosis." @default.
- W2375376576 created "2016-06-24" @default.
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- W2375376576 date "2008-01-01" @default.
- W2375376576 modified "2023-09-26" @default.
- W2375376576 title "Traditional Chinese Medicine Containing Pyrrolizidine Alkaloids and Hepatic Veno-Occlusive Disease" @default.
- W2375376576 hasPublicationYear "2008" @default.
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