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- W2375379033 abstract "Objective To study the reproductive toxicity of male rats exposed to 1-bromopropane and 2-bromopropane and to explore the toxic mechanism of two isomers. Methods 18 SPF SD male rats were randomly divided into 3 groups of 6 each, respectively. The groups were exposed to corn oil, 1-BP (1 g/kg) and 2-BP (1 g/ kg) for 7 days by intraperitoneally injection. Trait of reproductive organs, sperm characteristics, testicular histological and apoptotic findings and the lipid peroxidation in the testicular and epididymal tissue were determined. Results Results showed that treatment with bromopropanes induced reduction in sperm concentration and increments in abnormalities of sperm injuries to sperm quality. In addition, 1-BP increased GR activity (7. 42 +/- 2.98 vs. 4.25 +/- 1.18, P Conclusion This study indicates that bromopropanes can cause reproductive disorder in male rats, the rats treatment with 2-BP had more toxicity than that with 1-BP, and it might have different toxic mechanism between two isomers." @default.
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- W2375379033 date "2010-01-01" @default.
- W2375379033 modified "2023-09-24" @default.
- W2375379033 title "Reproductive toxicity of male rats exposed to two isomers of bromopropanes" @default.
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