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- W2375401204 abstract "Objective:To investigate the variation of serum transforming growth factor β 1 (TGF β 1) in patients with acute hepatitis,chronic hepatitis and liver cirrhosis and the role of TGF β 1 in the pathophysiologic process of liver fibrosis and cirrhosis.Methods:Serum TGF β 1 was detected by using a standard bioassay in 89 patients with liver disease (acute hepatitis 32,chronic hepatitis 22 and liver cirrhosis 35) and 20 healthy persons served as normal control.Results:The data showed that (1)the serum TGF β 1 in patients with acute hepatitis (1 91±0 48 ng/ml) were similar with those in controls (1 65±0 45 ng/ml, P 0 05);(2)the serum TGF β 1 in patients with chronic hepatitis (5 62±1 02 ng/ml) and liver cirrhosis (11 75±1 08 ng/ml) were significantly higher than those in controls ( P 0 05),and the serum TGF β 1 were higher in the patients with liver cirrhosis than those in chronic hepatitis ( P 0 05).Conclusions:We suggested there was no change of the serum TGF β 1 in patients with acute hepatitis,the serum TGF β 1 were significantly higher in chronic hepatitis and liver cirrhosis and those were higher in the patients with liver cirrhosis than those in chronic hepatitis.The TGF β 1 may reflect the severity of liver cirrhosis.The TGF β 1 play the role in the pathophysiologic process of liver fibrosis and cirrhosis.We suggested the TGF β 1 may be a mark of liver fibrosis and the blocker of the TGF β 1 may be a important drug in the treatment of liver fibrosis." @default.
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- W2375401204 date "2001-01-01" @default.
- W2375401204 modified "2023-09-22" @default.
- W2375401204 title "Study of Serum TGF β_1 of Patients in Liver Disease" @default.
- W2375401204 hasPublicationYear "2001" @default.
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