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- W2375405930 abstract "【Objective】To investigate the effects of transient intensive insulin therapy on the monocyte chemotactic protein-1(MCP-1) on the monocyte surface and nuclear factor-κB(NF-κB) expression in the monocyte of newly-diagnosed type 2 diabetic patients.【Methods】Totally 20 healthy normal controls and 20 patients diagnosed as type 2 diabetes were recruited.All patients were treated with intensive insulin therapy for 2 weeks.Samples of 5 mL blood were taken from ulnar vein on an empty stomach in the morning.Mononuclear cells were separated from whole blood.The MCP-1 and NF-κB expressions of the monocyte cells were measured by flow cytometry before and after treatment.And the changes of Homa-IR,white blood cell(WBC),N % were also analyzed before and after therapy.【Results】After 2 weeks of the treatment,the expression levels of MCP-1 and NF-κB of the monocytes were significantly decreased from(0.89±0.26) %,(15.53±2.49) % to(0.50±0.18) %,(12.22±2.80) % respectively(P 0.05).HOMA-IR,WBC and N % decreased significantly compared with those before treatment.The expression levels of MCP-1 and NF-κB had no obvious correlation with the change of Homa-IR,WBC and N %.【Conclusion】Type 2 diabetes is a kind of fortified inflammatory reactive state,intensive insulin therapy can decrease the expression of MCP-1 and NF-κB in the peripheral blood mononuclear cells,so insulin has the effect of alleviating inflammatory reaction except for lowering blood glucose in type 2 diabetics." @default.
- W2375405930 created "2016-06-24" @default.
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- W2375405930 date "2010-01-01" @default.
- W2375405930 modified "2023-09-23" @default.
- W2375405930 title "Effects of intensive insulin therapy on monocyte chemotactic protein-1 and nuclear factor-κB of newly-diagnosed type 2 diabetic patients" @default.
- W2375405930 hasPublicationYear "2010" @default.
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