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- W2375421934 abstract "AIM Artificial gravity is considered one of the most effective and rational countermeasures to cardiovascular deconditioning after spaceflight. The purpose of this work isto investigate counteracting effects of intermittent artificial gravity on changes in responsiveness of basilar arteries of tail suspended rats. METHODS Three wk Tail suspended rats were subjected to head up tilt (HUT) of various duration (2 h or 4 h, respectively) daily and their responses of perfused isolated basilar arterial rings to KCl were examined. RESULTS Maximal isometric contractile responses to KCl were significantly enhanced in arterial rings isolated from 3 wk tail suspended rats (7.07±0.49) mN as compared with those from simultaneous control rats (4.83±0.36) mN ( P 0.05). However, maximal isometric contractile responses to KCl in arterial rings isolated from 3 wk tail suspended plus daily HUT rats [HUT 4: (4.78±0.51) mN; HUT 2: (5.56±0.28) mN] were the same no different as compared with those from simultaneous control rats, and were significantly decreased ( P 0.05) as compared with those from 3 wk tail suspended rats. CONCLUSION Daily using the intermittent artificial gravity produced by HUT as a countermeasure can prevent the effects of simulated weightless on changes in responsiveness of basilar arteries of tail suspended rats is valid." @default.
- W2375421934 created "2016-06-24" @default.
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- W2375421934 date "2001-01-01" @default.
- W2375421934 modified "2023-09-25" @default.
- W2375421934 title "Counteracting effects of intermittent head-up tilt on changes in responsiveness of basilar arteries of tail suspended rats" @default.
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