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- W2375457029 abstract "Objective To evaluate the effect of craniotomy on the CSF drug concentration by measuring drug concentration in blood, in subcutaneous transudation and in CSF. Methods 40 patients enduring craniotomy were admitted in the study, 20 patients in the dura intact group, while another 20 in the dura open group. All patients were injected Gentamycin Sulfate 80 thousand unit preoperation. The drug level of Gentamycin in blood, subcutaneous transudation and CSF were determined at 6 hours after operation. Results Gentamycin concentration of the dura intact group: 0.47±0.15 in blood, 1.41±0.46 in subcutaneous transudation, 0.27±0.18 in CSF. That of subcutaneous transudation was the highest, blood was the second, CSF was the last, there were significant difference among these subgroups(P0.01); Gentamycin concentration of the dura opened group: 0.56±0.19 in blood, 1.28±0.75 in subcutaneous transudation, 0.52±0.15 in CSF, subcutaneous transudation was the highest also, but there were no significant difference between blood and CSF(P0.5). Compared the two groups, there were no significant difference between the blood drug levels, so were the concentration of the subcutaneous transudations (P0.5), but were significant difference between those of CSF. Conclusion The drug concentration in subcutaneous transudation is higher than that of in CSF, therefore drug concentration in CSF can rise by exchanging between endocranial and extracranial via opened dura." @default.
- W2375457029 created "2016-06-24" @default.
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- W2375457029 date "2005-01-01" @default.
- W2375457029 modified "2023-09-26" @default.
- W2375457029 title "The study of the effect of craniotomy on the CSF drug concentration" @default.
- W2375457029 hasPublicationYear "2005" @default.
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