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- W2375459634 abstract "Objective: To evaluate the effectiveness and safety of salvianolate injection( SI) on acute cerebral infarction( ACI) versus conventional treatment( CT). Method: Systematic literature searches were performed in Pub Med, Cochrane Library, CBM, CNKI and Wan Fang datbase from Jan 1994 to Apr2014. Randomized controlled trials( RCTs) on SI treating ACI were enrolled. Two reviewers screened articles according to the inclusion and exclusion criteria,extracted data and assessed the quality of the included studies independently. The Meta-analysis was performed using Rev Man 5. 2. Result: A total of 12 RCTs involving 1 574 patients were included. The results of Meta-analysis demonstrated that SI had higher curative rate [OR = 2. 78,95% CI( 1. 87,4. 12),P 0. 000 01] on 6 RCTs,improvement evaluation of NIHSS [OR =-2. 05,95% CI(-2. 51,-1. 59),P 0. 000 01]on 5 RCTs,and amendment many endothelia parameters as compared with the CT group. No severe adverse reactions after SI treatment were reported. Conclusion: Current evidence shows SI may be superior to CT in treating ACI patients in recovery rate,vascular endothelial cell protection and improvement hemorheology index. However,due to lack of enough high-quality studies,SI has to be further studied by conducting more strictly-designed,multicenter,large-scale and double-blind RCTs." @default.
- W2375459634 created "2016-06-24" @default.
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- W2375459634 date "2015-01-01" @default.
- W2375459634 modified "2023-09-24" @default.
- W2375459634 title "Effectiveness and Safety of Salvianolate Injection on Acute Cerebral Infarction" @default.
- W2375459634 hasPublicationYear "2015" @default.
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