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- W2375488908 abstract "Objective:To investigate the protection of ticagrelor on myocardium in patients with ST-segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention.Method:The data of 462 in-hospital patients with ST-elevation myocardial infarction who undergoing emergency percutaneous coronary intervention were enrolled.The patients were divided into 2 groups:In the ticagrelor group,ticagrelor was given in a loading dose of 180 mg followed by 90 mg twice daily.In the clopidogrel group,patients received a 300 mg loading dose of clopidogrel followed by 75 mg daily.The potential benefits of ticagrelor on myocardium injure and safety were recorded.Result:In the ticagrelor group,there were significant increasing in the rate of TIMI 3 flow(P=0.032)and ST segment resolution(P=0.045),and the peak of CKMB(P=0.017),TnI(P=0.037),CK(P=0.011)were lower than clopidogrel group.There was no significant difference in bleeding events and major adverse cardiovascular event(P0.05)between ticagrelor and clopidogrel although there was a trend in favor of coronary slow flow may be improved(P=0.061).Conclusion:Ticagrelor reduced myocardium injure and improved coronary flow in patients with ST-segment elevation myocardial infarction undergoing emergency percutaneous coronary interventionin without bleeding events increase." @default.
- W2375488908 created "2016-06-24" @default.
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- W2375488908 date "2015-01-01" @default.
- W2375488908 modified "2023-09-23" @default.
- W2375488908 title "Protection of ticagrelor on myocardium in patients with ST-segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention" @default.
- W2375488908 hasPublicationYear "2015" @default.
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