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- W2375492050 abstract "Objective: To study the effects of the IFN-γ, IL-4 levels on the correlation between the expression of Fas and Bcl-2 in public blood lymphocytes (PBLC) in the patients with Hemodialysis (HD). Methods: Indirect immune fluorescence labeling method of flow cytometry and solid sand with enzyme linked immune sorbent assay (ELISA) were performed for detecting the expression of Fas, Bcl-2 in PBLC and the levels of IFN-γ, IL-4 in serum of 30 cases with HD, respectively. Results: The expressions of Fas in PBLC with HD was significantly higher than that of normal control, but Bcl-2 was significantly lower (P0.01); The levels of IFN-γ in serum with HD was significantly lower than that of normal control, but IL-4 was significantly higher(both P0.01); The expressions of Fas in PBLC had a negative correlation with the levels of IFN-γin serum of patients with HD, but had a positive correlation with the levels of IL-4; The expressions of Bcl-2 had a positive correlation with the levels of IFN-γ, but had a negative correlation with the levels of IL-4 (P0.01). Conclusions: Patients with HD were characterized by the abnormal apoptosis in PBLC and the suppressed secretion of the Th1 associated with cytokines (eg: IFN-γ), the increased secretion on of the TH2 associated with cytokines (eg: IL-4). The two aspects may have a correlation and may play an important role in the immune pathogenesis of HD." @default.
- W2375492050 created "2016-06-24" @default.
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- W2375492050 date "2004-01-01" @default.
- W2375492050 modified "2023-09-25" @default.
- W2375492050 title "Effects of IFN-γ,IL-4 levels on expression of Fas and Bcl-2 in public blood lymphocytes (PBLC) in patients with Hemodialysis" @default.
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