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- W2375497772 abstract "Objective:Scorpion toxin is a neurotoxin,whose effects on the sodium channels of the peripheral nervous system are not yet quite clear,with a lot of questions to be studied.This study aimed to investigate the effects of scorpion polypeptide purified from Buthus martensi Karsch 224(BmK224) on the tetrodotoxin-sensitive sodium currents(TTX-S INa) in the isolated rat dorsal root ganglion(DRG) neurons.Methods: We isolated the dorsal root ganglion neurons from rats,and observed the effects of BmK224 on TTX-S INa using whole cell patch clamp recordings.Results: BmK224 blocked the whole cell TTX-S INa in a concentration-dependent manner.At the concentration of 40 μg/ml,it induced the negative shifting of the TTX-S INa activation curve,shifted the steady-state inactivation curve to the left,delayed the recovery of TTX-S INa from inactivation,and increased the fraction of available sodium channels.Conclusion: This study suggests that BmK224 contains α-scorpion toxins,which lead to the alteration of the conformation of sodium channels." @default.
- W2375497772 created "2016-06-24" @default.
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- W2375497772 date "2009-01-01" @default.
- W2375497772 modified "2023-09-24" @default.
- W2375497772 title "Effects of polypeptide purified from Buthus martensi Karsch on tetrodotoxin-sensitive sodium channels in rat dorsal root ganglion neurons" @default.
- W2375497772 hasPublicationYear "2009" @default.
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