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- W2375504703 abstract "Objective To investigate the role of Th17 cell associated cytokines of IL-23 and IL-17 in the pathogenesis of pemphigus vulgaris.Methods Immunofluorescence staining was performed to analyse the distribution of CD163~+ macrophages and expression of IL-23 and IL-17 in pemphigus vulgaris lesions and healthy human skin tissues.Results The staining of IL-23~+ cells is overlapped with that of CD163~+ macrophages.The mean numbers of IL-23 CD163~+ cells and IL-17~+ cells were 80.17±5.42 and 48.17±8.03 in each field of view(×200)in dermis of pemphigus vulgaris,while those in healthy human dermis were 29.50±4.45 and 9.50±3.35,with significant differences between dermis of pemphigus vulgaris and healthy human dermis(P0.01).The number of IL23~+ cells was related to that of IL-17~+ cells in dermis(r=0.945,P0.001).Conclusion IL-23 is mainly secreted by CD163~+ macrophages.IL-23 and IL-17 are overexpressed in pemphigus vulgaris lesions.IL-23/IL-17 cytokine axis may play an important role in the pathogenesis of pemphigus vulgaris." @default.
- W2375504703 created "2016-06-24" @default.
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- W2375504703 date "2010-01-01" @default.
- W2375504703 modified "2023-09-25" @default.
- W2375504703 title "Expression of Th17 cell associated cytokines in pemphigus vulgaris lesions" @default.
- W2375504703 hasPublicationYear "2010" @default.
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