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- W2375504829 abstract "Objective:To observe the apoptosis-related gene Bcl-2,nuclear factor NF-κB expression in hepatocellular carcinoma cells and to explore the relationship with AFP and its clinical significance.Methods:Immunohistochemical technique was used to detect the expression of Bcl-2,NF-κB in 40 cases of hepatocellular carcinoma(including 20 cases of AFP-positive,20 cases of AFP-negative) and 10 cases of benign tumor.The relationship between them and AFP was ananlyzed with Spearman correlation test with spss13.0.Results:The expression rate of Bcl-2 was 45%,NF-κB expression rate was 57.5% in 40 cases;in which expression of Bcl-2 in AFP-positive cells was 55%,AFP-negative cells was 35%;NF-κB expression in AFP-positive cells was 75%,in AFP negative cells was 40%.The expression of NF-kB protein and Bcl-2 protein was significantly positively correlated(r=0.778,P0.01) in hepatoma carcinoma cells.Conclusion:The abnormal expression of Bcl-2 and NF-κB have a certain relationship with tumor resistance to apoptosis and drug resistance,The expression rate of Bcl-2 and NF-κB is higher in AFP-positive cancer cells.Bcl-2 and NF-κB can be considered as a prognostic indicator." @default.
- W2375504829 created "2016-06-24" @default.
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- W2375504829 date "2011-01-01" @default.
- W2375504829 modified "2023-09-25" @default.
- W2375504829 title "Study of Bcl-2 and NF-kB expression in hepatocellular carcinoma cell and the relationship with AFP" @default.
- W2375504829 hasPublicationYear "2011" @default.
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