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- W2375508468 abstract "Objective To observe the characteristics of vasoconstriction caused by endothelin - 1 and determine the antagonistic effect of vasodilators. Methods Vasomotory test of the isolated rat common carotid artery was done to compare the influence of endothelin - 1 (ET - 1) and noradrenaline (NE)on artery tension in vitro, and detect the antagonistic effects of vasodilators on ET - 1 induced vasoconstriction. Results Endothelin - 1 resulted in a constant constriction which was concentration - dependent in isolated rat common carotid arteries. The median effective concentration (EC 50 ) of endothelin - 1 and noradrenaline were 1.8 × 10 -9 mol/L and 3.4 × 10 -8 mol/L respectively. The EC 50 of noradrenaline was 18.9 times of that of endothelin - 1. Lidocaine, nifedipine, papaverine, sodium nitroprusside, and anisodamine all relaxed endothelin - 1 - induced vasoconstriction. The strongest among those vasodilators was sodium nitroprusside, whereas lidocaine and anisodamine weaker. Conclusions Endothelin - 1 induces potent and persistent vasoconstriction of isolated arteries. Vasodilators can reduce endothelin - 1 - induced vasoconstriction." @default.
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- W2375508468 date "2001-03-10" @default.
- W2375508468 modified "2023-09-25" @default.
- W2375508468 title "Contractile effect of endothelin-1 on isolated artery and the antagonistic effect of vasodilators" @default.
- W2375508468 doi "https://doi.org/10.3760/cma.j.issn.1005-054x.2001.01.013" @default.
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