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- W2375521752 abstract "Objective: To observe the coexist expressive variety of estrogen receptor α(ERα) and β-site β-amyloid precursor protein cleaving enzyme(BACE) in the cerebral cortex and hippocampus CA1 of rat′s brain with fimbria/fornix transection and ovariectomy. Method:Twenty-eight healthy female rats were randomly divided into four groups, fimbria/fornix transection group(FF), ovariectomized group(OVX), fimbria/fornix transection and ovariectomized group(OF), control group. There were seven rats in every group. The bilateral fimbria-fornix of brain were transected in the stereotaxic apparatus according to Klein′s method and bilateral ovaries were ablated according to Singh′s method in order to establish rat′s model. Result: In cerebral cortex and hippocampus CA1 of brain of FF group, OVX group and OF group, amounts of green cells of ERα decreased remarkably than that in control group(cortex:4.71±1.11, 5.29±2.01, 4.42±3.99 vs 9.71±4.53;hippocampus: 6.91±2.63, 7.58±4.16, 5.14±3.80 vs 12.57±3.59, all P0.05) and the amounts of red cells of BACE improved remarkably than that in control group(cortex: 15.78±6.01, 17.63±4.42, 20.00±5.16 vs 5.71±3.14;hippocampus: 15.91±5.12, 12.34±5.07, 17.14±4.45 vs 6.85±1.95, all P0.05). Conclusion: Fimbria/fornix transection or ovariectomy can cause the expression of ERα positive neurons decreasing and BACE positive neurons increasing in cerebral cortex and hippocampus CA1 of rat′s brain, the combination fimbria/fornix transection and ovariectomy can cause double labeling cells improving in cerebral cortex." @default.
- W2375521752 created "2016-06-24" @default.
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- W2375521752 date "2007-01-01" @default.
- W2375521752 modified "2023-09-27" @default.
- W2375521752 title "Coexist expression and relation of estrogen receptor α and β-site β-amyloid precursor protein cleaving enzyme in rat′s brain with fimbria/fornix transection and ovariectomy" @default.
- W2375521752 hasPublicationYear "2007" @default.
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