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- W2375526035 abstract "Objective To study the expression of AQP-1 and AQP-3 in the pulmonary tissues of mice with acute lung injury induced by lipopolysaccharide and to clarify the relationship of ALI with the expression of AQP-1and AQP-3.Methods Forty healthy Sprague-Dawley mice were randomly divided into 4 groups:LPS 2h group,LPS 6h group,LPS 12h group and control group.ALI model was induced with LPS in all the LPS groups.Real-time PCR was used to observe the expression changes of AQP-1and AQP-3mRNA.Immunohistochemical method were used to determine the changes of AQP-1and AQP-3 protein in the pulmonary tissues of all the animals.Results Microscopic studies showed that there were not pathological changes in the lung tissue of rats in the control group.The most severest interstitial edema of lung and proliferation of epithelial cells were observed in the lung tissue of LPS6h group.The expression of AQP-1 mRNA were decreased in LPS2h group and significant reduction at LPS6h group(P0.05).The expression of AQP-3 mRNA had no obvious changes.Conclusion AQP-1 may play important roles in the abnormal ALI fluid transportation and might be assoiated with the development of pulmonary edema.AQP-3may not participate in the development of pulmonary edema during ALI." @default.
- W2375526035 created "2016-06-24" @default.
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- W2375526035 date "2013-01-01" @default.
- W2375526035 modified "2023-09-23" @default.
- W2375526035 title "Expression of AQP-1 and AQP-3 in pulmonary tissues of septic rats" @default.
- W2375526035 hasPublicationYear "2013" @default.
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