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- W2375538447 abstract "Objective To observe the treatment of malignant melanoma with TIL stimulated mailgant melanoma vaccines and IL-2 Dacarbazine et al.Methods 60 patients of advanced malignant melanoma were divided into two groups stochastically.The treatment group (30 patients) were treated with combined chemotherapied with the TIL 、IL-2 and DDAVC plan (DDAVC is a chemotherapy projecte which use the most of Dacarbazine and Cisplatin,Doxorubicin,Vincristine,Lomustine).The comparison group (30 patients)were treated with only chemotherapied with IL-2 and the DDAVC plan.Curative effects,life span,immunity level,toxical reaction between the two groups were compared.Results The overall response rates 73.3 of the treatment group was higher than response rates 43.3 of the comparison group(P0.05).The meso-lifes pan were 11 months in the treatment group and 7 months in the comparison group,1-and 2-years survival rate in the treatment group was 66.67 and 26.67 respectively,which were higher than those of in the comparison group,40 and 6.67(P0.05).The CD_3、CD_4、 CD_4/CD_8 ratio of the T cell subgroup in treatment group have the different degree of increase compared with the comparison group(P0.05).The NK activeness in the comparison group has descend significantly (P0.05) and in the treatment group has raised significantly(P0.05).There were no significant deviation toxical reaction in the two groups.Conclusion The TIL stimulated by malignant melanoma vaccine can enhance the immune activity of the organism and extend the life span of patients.The patients with late malignant melanoma after combined chemotherapied with IL-2、dacarbazine and TIL can achieve prospective curative effect." @default.
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- W2375538447 date "2006-01-01" @default.
- W2375538447 modified "2023-09-26" @default.
- W2375538447 title "Study of the treatment of malignant melanoma with TIL stimulated mailgnant melenoma vaccines" @default.
- W2375538447 hasPublicationYear "2006" @default.
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